Oncolytic viral therapies
نویسندگان
چکیده
منابع مشابه
Novel oncolytic viral therapies in patients with thoracic malignancies
Oncolytic virotherapy is the use of replication-competent viruses to treat malignancies. The potential of oncolytic virotherapy as an approach to cancer therapy is based on historical evidence that certain viral infections can cause spontaneous remission of both hematologic and solid tumor malignancies. Oncolytic virotherapy may eliminate cancer cells through either direct oncolysis of infected...
متن کاملClinical Considerations for Oncolytic Viral Therapies: A Regulatory Perspective.
The US Food and Drug Administration (FDA) approved the first oncolytic viral therapy (OVT), Imlygic (talimogene laherparepvec), in October 2015 for the local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in patients with melanoma recurrent after initial surgery, although talimogene has not been shown to improve overall survival or have an effect on visceral metastases.
متن کاملViral Oncolytic Therapy
The liver is a common site for primary or metastatic disease. In addition to primary liver tumors, such as hepatocellular carcinoma, cholangiocarcinoma, and gallbladder carcinoma, several cancers are known to present with isolated hepatic metastasis, including colorectal carcinoma, ocular melanoma, and neuroendocrine cancers. Moreover, in patients with additional sites of extrahepatic disease, ...
متن کاملExperimental therapies: gene therapies and oncolytic viruses. - PubMed - NCBI
Glioblastoma is the most common and aggressive primary brain tumor in adults. Over the past three decades, the overall survival time has only improved by a few months, therefore novel alternative treatment modalities are needed to improve clinical management strategies. Such strategies should ultimately extend patient survival. At present, the extensive insight into the molecular biology of gli...
متن کاملOncolytic Viral Therapy for Mesothelioma
The limited effectiveness of conventional therapy for malignant pleural mesothelioma demands innovative approaches to this difficult disease. Even with aggressive multimodality treatment of surgery, radiation, and/or chemotherapy, the median survival is only 1-2 years depending on stage and histology. Oncolytic viral therapy has emerged in the last several decades as a rapidly advancing field o...
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ژورنال
عنوان ژورنال: Cancer Gene Therapy
سال: 2004
ISSN: 0929-1903,1476-5500
DOI: 10.1038/sj.cgt.7700733